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Welcome to Discovery to Innovation

Discovery to Innovation is a quarterly update of news, research findings, and game-changing developments at
The Childrenʼs Hospital of Philadelphia Research Institute.

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Monica Bessler, MD, one of the world's leading experts in bone marrow failure and related blood disorders recently joined Children's Hospital. Dr. Bessler studies the molecular and genetic events that give rise to bone marrow failure in children and adults. Bone marrow failure can be inherited or acquired in many known forms. Often, however, the cause of bone marrow failure remains unclear.

At Children's Hospital, Dr. Bessler will continue her leading research in understanding the origins of bone marrow disease and will establish the Hospital's Pediatric and Adult Comprehensive Bone Marrow Failure Center. Her research goals include refining diagnostic tools and developing more effective and comprehensive treatments by targeting the reduced or abnormal production of blood cells in bone marrow failure. Because blood cells play key roles in a number of other important biological processes, better understanding of their production and functions may have medical implications beyond blood disorders.

For physician-in-chief Alan Cohen, MD, a pediatric hematologist himself, Dr. Bessler's new center represents a major advance in bone marrow diseases. "Dr. Bessler is recognized throughout the world as a leader in understanding the origins of these serious disorders, as well as their clinical manifestations and their management," he says. "She also enhances our ability to ensure a smooth transition for affected patients as they grow into adulthood."

Dr. Bessler, the first person to hold the Buck Family Endowed Chair in Pediatric Hematology at Children's Hospital, has brought several research grants to Children's Hospital from the National Institutes of Health and from the Department of Defense Congressionally Directed Medical Program for Bone Marrow Failure Research. Those projects join Children’s Hospital's already robust programs in pediatric genomics, stem cell, red blood cell, and blood platelet studies, and other translational research aimed at applying scientific discoveries to treatments for children.

Read the full press release.

Links of Interest

  • CHOP Research Institute Website +

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  • Bench to Bedside +

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  • CHOP Foundation Website +

    A Million Stories of Hope. Countless Reasons to Give Every story of hope at The Children’s Hospital of Philadelphia is Read More
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